J Med Chem,41, Ictal bradycardia and atrioventricular block: a cardiac manifestation of epilepsy. At baseline, patients were slightly overweight Control of post-prandial hyperglycemia-an essential part of good diabetes treatment and prevention of cardiovascular complications. To predict the adequacy of sample size the nQuery test was used. Due to the fact that postprandial glucose excursion is a strong cardiovascular risk factor in diabetics [ 7 Click here to see the Library8 Click here to see the Library9 Click here to see the Library et 10 Click here to see the Library ]one cannot rule out that repaglinide has also an impact on metabolic and coagulative factors related to cardiovascular risk. To date, the physiologic mechanism involved in the association between epileptic seizures and cardiac arrhythmias is poorly understood. Whether glimepiride and repaglinide have similar effects on postprandial glucose excursions and on cardiovascular risk factors is still not investigated. In our patient, bradycardia and asystole were documented by ECG monitoring which occurred after epileptic seizures that were only clinically observed. At time ' of meal test, repaglinide vs glimepiride administration was associated with a significant decline in plasma triglycerides, free fatty acids, fibrinogen, Plasminogen Activator Inhibitor-1, plasmin-alpha 2 -antiplasmin complex, thrombin-antithrombin complex, TBARS levels and increase in plasma HDL-cholesterol levels.
Corresponding author: Giuseppe Paolisso, so@ MD, PHD,; Raffaele Marfella, MD, PHD and; Giuseppe Paolisso, MD, PHD⇓. Corresponding author: Giuseppe Paolisso, so@ Diabetes Care Oct; 35(10): E-mail: so@ Affiliation Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric.
Three similar epileptic seizures, without the recurrence of asystolewere registered after pacemaker implantation.
Our results provide evidence that repaglinide is more efficient than glimepiride on controlling for post-prandial glucose excursions and may have beneficial effects on reducing cardiovascular risk factors.
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Neurol Clin ; Control of post-prandial hyperglycemia-an essential part of good diabetes treatment and prevention of cardiovascular complications.
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Professore di Medicina Interna. Email verificata su F Nappo, K Esposito, M Cioffi, G Giugliano, AM Molinari, G Paolisso. Università degli Studi di Napoli.
Seconda Università degli Studi di Napoli. Countries. Italy. Contact information. Giuseppe Paolisso, Rettore, rettorato@ unina2. (2)Department of Geriatric Medicine and Metabolic Disease, Second University of Naples, Italy. so@ BACKGROUND.
Oral hypoglycemic agents: insulin secretagogues, alpha-glucosidase inhibitors and insulin sensitizers. Diabetes Res Clin Pract,59, Article Article Outline.
A comparison of repaglinide and glibenclamide in the treatment of type 2 diabetic patients previously treated with sulphonylureas. His two brothers with epilepsy both suddenly died of unspecified heart disease at the ages of 26 and 53, respectively.
Endothelial dysfunction is recognized as a key early. Giuseppe Paolisso, Department of Geriatric Medicine and Metabolic Diseases, E‐mail:E-mail address:so@
Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly.
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K jlBPliti. Furthermore, as well as repaglinide, glimepiride is also initiating insulin secretion by closing K-ATP channel. However, long-term studies will need to determine whether greater improvements in those cardiovascular risk factors will translate into a reduced incidence of cardiovascular diseases. Our results provide evidence that repaglinide is more efficient than glimepiride on controlling for post-prandial glucose excursions and may have beneficial effects on reducing cardiovascular risk factors.
In addition, this patient also had a strong family history of epilepsy and sudden death probably from heart disease.
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|Nevertheless, implantation of cardiac pacemaker along with the administration of antiepileptic drugs may be necessary Fig.
Furthermore, the patient's two brothers suddenly died of unspecified heart disease at the ages of 26 and 53, respectively.
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Labs, Italy. Baseline electroencephalogram EEGperformed a few days later, showed dominant 7 Hz sub-alpha activity admixed with slower elements theta rhythm: Hz prevailing in frontocentral right regions, sometimes with spike morphologies. Diabetes Care,19, Three similar epileptic seizures, without the recurrence of asystole, were registered after pacemaker implantation.