ENSP 21 P 20 Urinary bladder Urothelial cells:. Cyagen custom transgenic mouse and rat models for MEF2C. Toggle navigation. Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile. Tissue specificity: Expressed in brain and skeletal muscle. MEF2C 35
Here, we report that MEF2C plays a critical function as an inhibitor of endothelial cell inflammation. Tumor necrosis factor (TNF)-α inhibited MEF2C expression in.
Video: Mef2 endothelial function Mechanisms of Vascular Dysfunction in Diabetes (Joshua A. Beckman, MD) Feb 23, 2017
), play a role in the regulation of most endothelial-expressed genes (De Val and. Although MEF2 transcription factors have been implicated in vascular.
The C-terminal regions of MEF2 proteins, which function as transcriptional . MEF2 proteins are expressed in developing endothelial and smooth muscle cells .
We find that the MEF2C null mouse is defective in both cardiac and vascular morphogenesis.
Detectable Yes No. Genes that share disorders with MEF2C: view. A gene will only have one location and the categories and their hierarchy is: Intracellular and membrane, Secreted to blood,Secreted in brain,Secreted to digestive system, Secreted in female reproductive system, Secreted in male reproductive system, Secreted to extracellular matrix, Secreted in other tissues, Secreted - unknown location Read more.
Tissue expression of MEF2C Summary The Human Protein Atlas
Q [Direct mapping] Myocyte-specific enhancer factor 2C Show all. Colon Endothelial cells:. Appendix Glandular cells:.
Endothelial-specific Mef2c deletion resulted in marked changes in the.
The mutant heart contracts in a peristaltic motion but there is no visible flow of blood outside of the heart. Parathyroid gland. Lymph node Germinal center cells:. Male tissues. Another set of experiments will attempt to determine the relative contribution of the malformed heart to the vascular defects by rescuing the heart defects through specific expression of MEF2C in the hearts of MEF2C null mice.
Functions of MEF2 in Vascular Development John Schwarz
Mef2 endothelial function
|Cerebral cortex Glial cells:. ENSG version MEF2C Protein expression data is shown for each of the 44 tissues. Hippocampus Neuronal cells:.