Blood was collected, pooled and incubated with erythrocytes lysing solution for 5 min at room temperature. OriGene clones in humanmouse for NEO1. Actin was stained using monoclonal rabbit anti- Actin Cell Signaling. Nat Neurosci 4: Suppl— One of these parallels is the function of neuronal guidance proteins NGP s that were initially described in the context of axonal migration but were demonstrated to also serve as endogenous guidance cues for leukocyte migration.
View mouse Neo1 Chr with: phenotypes, sequences, ( MPD) · Deltagen and Lexicon Knockout Mice · International Mouse Phenotyping neogenin. Synonyms.
H22Rik, DN22Rik, Igdcc2. Feature Type.
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse. View mouse Dcc Chr with: phenotypes, sequences, polymorphisms, proteins, references, function, expression.
Neo1 MGI Mouse Gene Detail MGI neogenin
Neogenin deficient mice were impaired in digit/limb development and. was also observed in the growth plates of 2–3 weeks old mutant mice (data not shown ).
Mice were injected i. For example, Slit-2 and Netrin-1 were reported to serve as stop signal for the migration of granulocytes, lymphocytes, monocytes and dendritic cells  — . To date, several families of these neuronal guidance proteins NGP s were described outside the central nervous system CNSamongst these are the slits, semaphorins, netrins and the repulsive guidance protein family, where they act as guidance cues for the migration of granulocytes, lymphocytes, monocytes and dendritic cells  — .
Science — View Article Google Scholar 6.
Video: Neogenin knockout mice database Cre-LoxP Recombination
First evidence that neogenin might be involved into the control of an acute inflammatory response came from our previous study describing the role of RGM-A during an acute inflammatory response.
as mutations or abnormal levels and includes techniques such as knockouts. Organism-specific databases. Hide 10 20 30 40 MAAEREAGRL LCTSSSRRCC PPPPLLLLLP LLLLLGRPAS GAAATKSGSP 60 70 80 90 PQSAGASVRT FTPFYFLVEP.
Again, we performed histological evaluation of the inflammatory changes within the peritoneal cavity following i.
Loss of haematopoietic neogenin decreases acute peritoneal inflammation.
NEO1 Gene GeneCards NEO1 Protein NEO1 Antibody
Based on the fact that NGPs hold important function outside the CNS we pursued the role of neogenin during an acute inflammatory response. J Immunol — Promoters and enhancers for NEO1 Gene.
JOBON LIGHTERS OFFICIAL VIDEO
|Chimeric animals and controls were injected i.
Video: Neogenin knockout mice database Why use the Mouse Genome Informatics (MGI) database?
A crucial target receptor for NGPs during embryonic development is the neogenin receptor, however its role during acute inflammation is unknown. In addition we found a robust expression of neogenin on CD45 positive cells which implicates neogenin to be present on immune competent cells.
Haematopoetic neogenin is crucial for inflammatory control following peritonitis Based on the above studies we aimed to identify whether tissue specific or haematopoetic neogenin expression would be responsible for the findings described above.
Neuronal guidance proteins NGP were originally described in the context of axonal growth and migration. This was confirmed when evaluating the MPO activity and the protein content within the peritoneal lavage Figure 6B and C.